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Single-step Method for Purification of Bacteriophage VDX-10 on CIM® QA Disk Monolithic Column and Method Scale-up

AN027-Bacteriophage VDX_QA disk_2010_1
AN027-Bacteriophage VDX_QA disk_2010_1AN027-Bacteriophage VDX_QA disk_2010_2

Bacteriophages are used in a broad range of applications, including phage therapy and phage display. With the growing problem of antibiotic resistance leading to untreatable bacterial infections, they are becoming very interesting as antimicrobial agents, not only in medicine, but also in veterinary medicine, food industry and agriculture. Phages intended for use as antimicrobial agents, especially those for human use, need to be purified of contaminants.

Here we present efficient single step purification method for a Staphylococcus aureus phage VDX-10 from bacterial lysate on a CIM® QA Disk Monolithic Column (Figure 1). The described method can be used also on a larger scale using a CIM® QA-8 mL Tube Monolithic Column (Figure 2).


CIMmultus™ QA-1 Advanced Composite Column (Quarternary amine) (Pores 2 um)Information
CIMmultus™ DEAE-1 Advanced Composite Column (Diethylamino) (Pores 2 um)Information

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