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Immobilisation of proteins onto CIM® – developing the most efficient affinity chromatographic monolith

Differently pre-activated CIM® monoliths enable immobilisation of a range of proteins, peptides, nucleotides and other affinity ligands. The first parameters to be defined for a new immobilisation are the activation chemistry of the matrix and the linkage protocol. Due to the varying physico-chemical characteristics of different ligands, however, a platform process cannot be achieved.


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