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Conjoint liquid chromatography on CIM® monoliths in speciation of Pt-based chemotherapeutics in human serum

For better understanding of anticancer therapy with Pt-based chemotherapeutics, the quality of pharmaceutical formulations must be assured and the behaviour of the drugs studied by separation and detection of the intact drug and its individual biotransformation species in clinical samples at therapeutically relevant levels. To study the interactions of Pt-based chemotherapeutics with serum proteins, two-dimensional chromatographic separation of serum proteins was suggested, combining size-exclusion and CIM DEAE monolithic.6 Since this procedure is time consuming the potential of the use of CLC was investigated.


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