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Native elution in immunoaffinity chromatography enables highly effective virus purification

Downstream processing of viruses in virus vaccine or virus vector production accounts for up to 70% of the overall production costs. Immunoaffinity chromatography is a powerful purification technique due to its high specificity but is disadvantaged by the fact that the elution of the target molecule requires conditions for disrupting interactions between antigen and the antibody and these are often detrimental for both the immobilized proteins and target antigens, especially viruses. Here we describe the mumps virus purification using monolith-based immunoaffinity stationary phase and recently invented native elution of the bound viruses using amino acid solutions under physiological pH.


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