Leaders in monolith chromatography


    EDA (ethylendiamino) is a weak anion exchanger which selectively binds biomolecules with predominant negative charge over a working pH range of 3-9. In contrast to DEAE or QA monoliths it contains free primary amino groups, resulting in a promotion of not purely ion-exchange interaction. Due to additional interactions with the biomolecules the ligand could be defined as a salt-talerant one, needing higher concentrations of NaCl for biomolecules elution compared to DEAE or QA. Besides ion-exchange character EDA can be used as a precursor spacer arm, which is after the reaction with glutaraldehyde able to immobilize macromolecules with primary amino groups. The eight atom spacer arm between the immobilized protein and matrix belongs to a secondary amino group, which represent a hydrolytically stable covalent linkage.

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