CIM® QA-0.34 mL is a shallow, disk-shaped monolith with a column volume of 0.34 mL. It is predominantly suitable for initial screening and method development. The CIM® QA-0.34 mL disk needs to be inserted into a housing and is immediately ready for use. QA (quaternary amine) is a strong anion exchange group, fully charged between pH 2-13. It selectively binds molecules with a predominant negative charge over a working pH range of 2-13. QA is a versatile chemistry and has proven to be excellent for:
- Capture, intermediate, or polishing steps of downstream processing
- Purification and concentration of viruses, VLPs, and large proteins
- Removal of endotoxins and DNA. Its high binding capacity for these molecules makes QA your tool of choice during the polishing step.
Due to the difference in chemistry of QA (strong anion exchanger) and DEAE (weak anion exchanger), selectivities for a certain molecule are different.
Read more: axial flow, Conjoint Liquid Chromatography (CLC)