CIMmultus™ is the first true multi-use column. Its innovative, advanced composite housing offers the performance of a stainless steel column for the price of a single-use column.
Table: CIM® Stainless Steel Columns vs. CIMmultus™ Advanced Composite Columns - matching characteristics
Our engineers designed CIMmultus™ with safety in mind. The column's structural integrity and leachable profile match medical grade stainless steel but has the process economics of a single or multi-use device.
With the introduction of composite materials into an epoxy-based housing and the application of USP Class VI Parylene C coating to the entire column surface, CIMmultus™ offers:
- cGMP Compliance
- High Performance
- Low weight but high strength
Leachables are a concern to all manufacturers. CIMmultus™ addresses this concern by applying Parylene C to the entire surface of the housing. Parylene C is an inert substance with a well-proven safety record as a coating for permanent medical implants.
CIMmultus™ has a layer of carbon fiber embedded in the epoxy thermoset walls well away from the contact surface. This layer gives the column the same structural strength of a stainless steel column ensuring maximum safety.
CIMmultus™ is a versatile separation device. It is economical as a single use device, as a multi-use device (intra-batch or inter-batch use), and above all, it can be used at any step in the separation of complex biomolecules:
- Impurity removal (intermediate step or final polishing)
- Separation of complex samples
CIMmultus™ contains an improved CIM® monolithic technology, distinguished by 2 µm flow-through channels. They allow convective mass transfer of large biomolecules, making these columns a perfect choice for the purification of viruses, VLPs, plasmids, antibodies, PEGylated proteins and other big molecules.
CIMmultus™ stands for:
- Convective mass transfer, reduced backpressure and minimal sample clogging
- Fast product isolation and concentration of diluted samples
- Efficient removal of high molecular mass impurities in polishing steps
CIMmultus Advanced Composite Column