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The Use of Monolithic Polymeric Sorbents to Simulate Virus-Cell Interactions

I. V. Kalashnikova, N. D. Ivanova, T. B. Tennikova

Russian Journal of Applied Chemistry, 2008, Vol. 81, No. 5, pp. 867-873

A simple virus-cell complementary model system can be obtained using polymer-analogous reactions of the epoxy groups of glycidyl methacrylate-ethylene glycol dimethacrylate monolithic macroporous polymeric support and of the carboxy groups of styrene-methyl methacrylate polymeric nanospheres. The effect of thus designed microenvironment on the affinity binding parameters of virus-mimicking nanoparticles with the functionalized sorbent surface is studied by high-performance monolithic disk affinity chromatography.

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